The roles of m6A-modified regulatory factors in the development of malignant tumors
10.3760/cma.j.cn112150-20241208-00985
- VernacularTitle:m6A修饰调节因子在恶性肿瘤发生发展中的作用
- Author:
Kun HE
1
;
Xi ZHOU
;
Jing LI
;
Jinquan WANG
;
Ping LI
;
Ping TAN
;
Xiaobing XIE
Author Information
1. 湖南中医药大学第一附属医院医学检验中心，长沙 410007
- Publication Type:Journal Article
- Keywords:
Neoplasms;
RNA methylation;
N-methyladenosine;
Gene expression regulation;
Methyltransferases
- From:
Chinese Journal of Preventive Medicine
2025;59(5):716-727
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine (m6A) modification, as a widespread and high-profile type of epigenetic modification, can dynamically and reversibly regulate the whole process of RNA metabolism. This modification governs RNA stability, splicing, and translation via m6A regulators, which are categorized as Writers, Erasers, and Readers. m6A modification also plays a critical role in the development of tumors. Disruptions in the homeostasis of m6A modification levels lead to dysregulation of m6A regulators. Consequently, these dysregulated regulators modulate the proliferation, migration, and invasion of tumor cells and interfere with the normal functions of suppressor genes and oncogenes. This article aims to comprehensively elucidate the specific regulatory impacts of m6A modification on tumor-related gene expression. It focuses on the regulatory mechanisms of m6A modification on mRNA stability. Additionally, it explores the influence of m6A on the molecular translation of key signaling pathways. Moreover, it investigates the indirect regulatory effects mediated by non-coding RNAs (ncRNAs), etc. The intention is to offer a novel analysis of the pathogenesis of cancer at a new level, and also provide a theoretical basis for finding new effective treatment methods.
