Treatment of Alzheimer's disease through deep cervical lymphaticovenous anastomosis?

VernacularTitle:颈深部淋巴管静脉吻合术治疗阿尔茨海默病？
Author: Suyue PAN ¹
Author Information

1. 南方医科大学南方医院神经内科，广州　510515
Publication Type:Journal Article
Keywords: Deep cervical lymphaticovenous anastomosis; Alzheimer's disease; Glymphatic system; Neurofluid; Interstitial fluidopathy of central nervous system; Idiopat
From: Chinese Journal of Microsurgery 2025;48(3):283-287
CountryChina
Language:Chinese
Abstract: Deep cervical lymphaticovenous anastomosis (dcLVA) has gained momentum in China as an innovative treatment for Alzheimer's disease (AD), but the research about it is limited. This article reviews the research on the glymphatic system (GS) as an introduction, followed by the concepts and diseases related to neurofluid and interstitial fluidopathy of the central nervous system. The relationships between AD and idiopathic normal pressure hydrocephalus (iNPH) is then discussed. It further proposes that dcLVA could alleviate AD symptoms by modulating iNPH-like pathophysiology. Finally, current limitations are highlighted in terms of the applications of dcLVA, and the urgency to establish multidisciplinary teams for rigorous clinical trials and develop consensus to standardise the treatment of AD with dcLVA are emphasised, so that the innovative treatment technique of dcLVA that is developed in China can have sufficient evidence and benefit more AD patients.