Research progress on the association between prenatal nutritional factors and autism spectrum disorder

VernacularTitle:孕期营养因素与孤独症谱系障碍的研究进展
Author: Wenli ZHAO ¹ ; Changlu PAN ¹ ; Dongdan LI ¹ ; Jie YAN ¹ ; Hongmei HUANG ¹
Author Information

1. 国家儿童医学中心　首都医科大学附属北京儿童医院临床营养科，北京100045
Publication Type:Journal Article
Keywords: Autism spectrum disorder; Nutrition; Pregnancy
From: Chinese Journal of Preventive Medicine 2025;59(9):1559-1565
CountryChina
Language:Chinese
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental condition originating in early life, presenting significant challenges for affected families and society. ASD is characterized by atypical brain development occurring throughout gestation. Maternal diet during pregnancy plays a crucial role in ASD pathogenesis. Specifically, prenatal multivitamin supplementation and adequate vitamin D intake may reduce ASD risk; similar protective effects have been associated with polyunsaturated fatty acid (PUFA) and iron consumption. Although research findings are inconsistent, prenatal nutritional interventions represent a promising strategy for mitigating the future risk of mental health and other disorders in offspring. Therefore, this article reviews key nutrients implicated in ASD risk during pregnancy, to provide a theoretical foundation for developing precise perinatal nutritional intervention plans.