Research progress on prevention of peripheral nerve adhesions
10.3760/cma.j.cn441206-20240531-00138
- VernacularTitle:预防周围神经粘连的研究进展
- Author:
Yiran QIU
1
;
Dongxu HUANG
1
;
Xu GONG
1
Author Information
1. 吉林大学第一医院骨科中心手足外科，长春 130021
- Publication Type:Journal Article
- Keywords:
Peripheral nerve adhesions;
Neural scar;
Biological materials;
Drugs;
Peripheral nerve injury;
Neuropathy
- From:
Chinese Journal of Microsurgery
2025;48(1):107-112
- CountryChina
- Language:Chinese
-
Abstract:
Trauma or surgical intervention in peripheral nerves can lead to traumatic nerve scarring and adhesions, which could hinder nerve regeneration and potentially cause functional impairment. Extensive scarring and adhesions may compress nerves, impair the essential gliding ability and result in fibrosis within the nerves and surrounding tissues. Therefore, searching for effective anti-adhesion strategies to prevent scar formation has become a significant clinical challenge. Currently, the mechanisms underlying the formation of peripheral nerve adhesions are not yet fully understood, and there are limited clinical methods available to prevent the adhesions. This review summarise the preclinical research findings and potential mechanisms of various anti-adhesion strategies, including pharmacological approaches, physical barriers, physical methods, and the combination of them. Additionally, clinical trials and case-control data are evaluated to assess the effectiveness of anti-adhesion strategies that have been applied in clinical settings, providing insights into the potential for future clinical applications of the strategies in prevention of peripheral nerve adhesions.
