Analysis on adverse events following immunization of 299 219 children who received the fifth dose of diphtheria, tetanus and acellular pertussis combined vaccine in Shandong Province
10.3760/cma.j.cn112150-20240806-00626
- VernacularTitle:山东省299 219名儿童接种第5剂次无细胞百白破联合疫苗后的疑似预防接种异常反应分析
- Author:
Meng XIE
1
;
Xia FENG
1
;
Huifeng SUN
1
;
Ping XIONG
1
;
Weiyan ZHANG
1
;
Qing XU
1
;
Min ZHAO
1
;
Li ZHANG
1
Author Information
1. 山东省疾病预防控制中心免疫预防管理所，济南 250014
- Publication Type:Journal Article
- Keywords:
Diphtheria, tetanus and acellular pertussis combined vaccine;
Adverse event following immunization;
Fifth dose
- From:
Chinese Journal of Preventive Medicine
2025;59(4):474-477
- CountryChina
- Language:Chinese
-
Abstract:
From July 23, 2018, to December 31, 2019, a total of 299 219 children in Shandong Province received the fifth dose of the diphtheria, tetanus, and acellular pertussis combined vaccine (DTaP). Among these recipients, the distribution by age was as follows: 20 children under 2 years old (0.01%), 273 996 children aged 2 years (91.57%), 20 242 children aged 3 years (6.76%), 3 932 children aged 4 years (1.31%), 963 children aged 5 years (0.32%), and 66 children aged 6 years and above (0.02%). In total, 1 972 cases of adverse events following immunization (AEFI) were reported after the administration of the fifth dose of DTaP, resulting in an incidence rate of 659.05 per 100 000 doses. Among these, 1 718 cases were classified as common vaccine reactions, with an incidence rate of 574.16 per 100 000 doses, while 247 cases were identified as rare reactions, yielding an incidence rate of 82.55 per 100 000 doses. The incidence of AEFIs, as well as the rates of common and rare reactions, exhibited a significant increasing trend with the number of doses administered (all P<0.001). Among the rare reactions, there were 10 cases classified as severe, resulting in a reported incidence of 3.34 per 100 000 doses.
