Research advances in microscopic Monte Carlo simulations of FLASH irradiation
10.3760/cma.j.cn112271-20250708-00235
- VernacularTitle:FLASH照射的微观尺度蒙特卡罗模拟研究进展
- Author:
Hongyu ZHU
1
;
Ankang HU
;
Youfang LAI
;
Yuchen YANG
;
Xiaowu DENG
Author Information
1. 中山大学肿瘤防治中心放疗科，广州 510060
- Publication Type:Journal Article
- Keywords:
FLASH irradiation;
Monte Carlo simulation;
Radiobiological effect
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(11):1157-1164
- CountryChina
- Language:Chinese
-
Abstract:
FLASH irradiation (FLASH-IR) is one of the cutting-edge research directions in the field of tumor radiotherapy. Previous studies have demonstrated that FLASH-IR can effectively eradicate tumors while significantly reducing damage to normal tissues, exhibiting unique biological effects characterized by high efficiency and low toxicity. Monte Carlo simulation at the microscopic scale is a critical method for studying radiobiological effects and has been widely applied in conventional radiotherapy research. In recent years, its application in microscopic reaction analysis and mechanistic exploration of FLASH-IR has grown rapidly. This article systematically reviews the latest advances and key challenges in microscopic Monte Carlo simulation studies of FLASH-IR, aiming to provide theoretical insights and method ological guidance for future research.
