Potential of natural plant products in prevention and treatment of radiation-induced intestinal injury
10.3760/cma.j.cn112271-20240920-00368
- VernacularTitle:天然植物产物在放射性肠损伤中的防治潜力
- Author:
Siyuan LI
1
;
Liwei XIE
;
Ye TIAN
Author Information
1. 张家港市第一人民医院肿瘤科，张家港 215600
- Publication Type:Journal Article
- Keywords:
Natural product;
Radiation-induced intestinal injury;
Radiotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(9):911-919
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced intestinal injury (RIII), a common intestinal adverse reaction to radiotherapy in patients with abdominal and pelvic malignant tumors, affects the quality of life of patients and limits the clinical efficacy of radiotherapy. However, there is no breakthrough in the prevention and treatment of RIII in clinical practice. Natural plant products generally have the advantages of mild effects and few adverse reactions, providing abundant potential active ingredients for the prevention and treatment of RIII, including polyphenols, alkaloids, polysaccharides, and saponins. The underlying mechanism includes inhibiting oxidative stress, inhibiting cell apoptosis, regulating the expression of inflammatory factors, protecting intestinal crypt stem cells, and regulating intestinal flora. The review summarized these natural plant products against RIII and explored its mechanisms of action, in order to provide a theoretical basis for future drug development based on natural plant products.
