Role of microenvironment in the pathogenesis of kidney stone
10.3760/cma.j.cn112330-20250608-00240
- VernacularTitle:微环境在肾结石发病机制中的作用
- Author:
Tianxiang ZHANG
1
;
Xi ZHANG
1
;
Chunjiang HU
1
;
Bo XIAO
1
;
Jianxing LI
1
Author Information
1. 清华大学附属北京清华长庚医院泌尿外科 清华大学临床医学院，北京 102218
- Publication Type:Journal Article
- Keywords:
Kidney calculi;
Microenvironment;
Pathogenesis
- From:
Chinese Journal of Urology
2025;46(10):791-795
- CountryChina
- Language:Chinese
-
Abstract:
Kidney stone is a common urological disorder with an increasing annual incidence，posing a heavy social burden. Previous studies have demonstrated that diverse cell death modalities，including ferroptosis and apoptosis，induce renal tubular epithelial cell injury and thereby promote kidney stone formation. Emerging evidence in recent years has further revealed that immune-inflammatory responses driven by interactions among renal microenvironment components also contribute to kidney stone pathogenesis. This review systematically summarizes current research advances on the mechanisms by which inflammatory cellular components（e.g.，macrophages，T cells），inflammatory mediators（e.g.，inflammasomes，cytokines），microbiota，and their synergistic interactions influence kidney stone development within the renal microenvironment.
