A study and application of rapid and precise dose measurement based on Gafchromic EBT4 film in FLASH radiotherapy
10.3760/cma.j.cn112271-20250710-00246
- VernacularTitle:基于EBT4胶片的FLASH放疗快速精确剂量测量研究与应用
- Author:
Yi ZHANG
1
;
Yiwei YANG
;
Yinghong TANG
;
Shilan WANG
;
Peng WU
;
Qin YANG
;
Xufan HUANG
;
Yin LUO
;
Yu JIANG
;
Wenjun LUO
;
Guiqiang ZOU
;
Hua FENG
;
Yinxiang HU
Author Information
1. 贵州医科大学附属医院 贵州医科大学附属肿瘤医院肿瘤科，贵阳 550024
- Publication Type:Journal Article
- Keywords:
FLASH radiotherapy;
EBT film;
RGB value;
Net optical density
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(11):1144-1151
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a rapid and precise dose measurement method with EBT4 film and ensure its measurement accuracy to be within the required range through strict operational procedures for the purpose of addressing the two essential issues of poor measurement accuracy and timeliness of EBT film under FLASH conditions.Methods:After storing under different humidity conditions for a certain period of time, the film was exposed to radiation for analyzing the influence of air humidity on the intrinsic performance of EBT film. By means of repeated scanning operations and the film angle rotation, the influences of repeated scanning and film placement angle were analuzed. Parabolic correction method was used to reduce the spatial position influence during the scanning process. By analying the relationship between net optical density (netOD) and absorbed dose through the comparison of three fitting method, the optimal fitting curve was selected. After irradiation of the same batch of films for 5 min and 24 h, the film doses were calibrated and then compared with ionization chamber-measured result. The rapid and precise film dosimetry method was used to measure both the percentage depth dose from X-rays at ultra-high dose rate and the dose distribution at a depth of 2 cm in water.Results:Air humidity had the greatest influence on the intrinsic performance of EBT film (approximately 20%). The average deviation of repeated scans is within 0.5%. The angle at which the film is placed significantly affected the readouts of the film with the maximum influence approximately 70%. The net optical density combined with polynomial fitting can control the fitting residuals of 1-16 Gy within 3%. The change rate of light channels at 5 min already mostly met the requirements of the rapid mode (< 0.5%). Compared with the measurement result obtained using the reference ionization chamber, the deviations of the 5 min or 24 h dose calibration curves were all within 2%.Conclusions:The EBT4 film can be employed as a precise dosimeter to quickly measure the FLASH radiation dose. Rapid and precise FLASH dose measurements can meet the stringent requirements of both preclinical and clinical FLASH research.
