Application and progress of nanomaterials in the treatment of radiation injury
10.3760/cma.j.cn112271-20250325-00108
- VernacularTitle:放射损伤救治中纳米材料的应用及研究现状
- Author:
Jianzhong HUA
1
;
Juancong DONG
;
Xuhong DANG
;
Xinran JIA
;
Jinhuan YU
;
Xiaoming LIU
Author Information
1. 中国辐射防护研究院，太原 030006
- Publication Type:Journal Article
- Keywords:
Nanomaterials;
Radiation injury;
Decorporation
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(10):1032-1040
- CountryChina
- Language:Chinese
-
Abstract:
The applications of nuclear technology in industries, medicine, and other fields have increased the risk of radiation injury. Although some small-molecule drugs for radiation injury treatment have been applied clinically or are in preclinical research, their therapeutic efficacy is significantly limited by short circulation time and rapid metabolism. Nanomaterials have attracted growing attention with their outstanding bioactivity, chemical stability, tissue compatibility, and targeted delivery capabilities, therefore having the promise of offering the potential solutions to the limitations of current small-molecule drugs. However, their biosafety and clinical efficacy require further investigation. This review summarizes the design strategies and classifications of nanomaterials for radiation injury treatment, analyzes current research progress in their therapeutic applications, and introduces nanomaterial-based approaches for enhancing the elimination of internal radionuclide contamination. Finally, the challenges and future prospects of nanomaterials in radiation injury treatment are discussed. This review aims to provide researchers with a comprehensive understanding of recent advances in nanomaterial-based radiation injury therapeutics, thereby promoting further development in this field.
