Role of mitochondria in pathological changes of radiation-induced intestinal injury and advances in research on mitochondria as potential targets for prevention and treatment
10.3760/cma.j.cn112271-20241223-00489
- VernacularTitle:线粒体在肠道辐射损伤病变中的作用及作为潜在防治靶点的研究进展
- Author:
Difan WANG
1
;
Shang CAI
Author Information
1. 苏州大学苏州医学院，苏州 215004
- Publication Type:Journal Article
- Keywords:
Radiation-induced intestinal injury;
Mitochondria;
Reactive oxygen species;
Apoptosis;
Mitochondrial autophagy
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(10):1025-1031
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced intestinal injury (RIII) is identified as a common complication of radiotherapy. However, there exists a lack of safe and effective treatment method. To address this issue, researchers have made great efforts to explore the mechanisms underlying RIII, revealing that mitochondria contribute to the pathological changes of RIII, with the mitochondria-mediated generation of reactive oxygen species (ROS), the regulation of apoptosis, and mitochondrial autophagy representing key processes. This review aims to elucidate the role of mitochondria in pathological changes of RIII and to introduce the progress of research on mitochondria as potential targets for RIII prevention and treatment.
