The progress on the role of ferroptosis in oxidative stress in BPH

VernacularTitle:铁死亡在良性前列腺增生氧化应激中作用机制的研究进展
Author: Shaofeng CHEN ¹ ; Chunxu LI ; Jiang WANG ; Fu WANG ; Qiang GENG ; Zhong LI ; Feng ZHAO ; Yuan SUN
Author Information

1. 天津中医药大学第一附属医院/国家医学中心/国家针灸临床医学研究中心男病科，天津　300183
Publication Type:Journal Article
Keywords: Ferroptosis; Oxidative stress; Benign prostatic hyperplasia
From: Chinese Journal of Urology 2025;46(8):636-640
CountryChina
Language:Chinese
Abstract: Ferroptosis is an emerging form of regulated cell death characterized by iron-dependent lipid peroxidation and the failure of the antioxidant system，which results in iron-dependent oxidative damage to the cell membrane. Ferroptosis is implicated in various biological processes，including cell proliferation，aging，and differentiation. The regulation of oxidative stress by ferroptosis is closely associated with the inactivation of glutathione peroxidase 4（Gpx4），dysfunction of the cysteine/glutamate antiporter System Xc-，the production of reactive oxygen species derived from oxidized polyunsaturated fatty acids，and alterations in lipid metabolism. Oxidative stress is a critical mechanism underlying the onset and progression of benign prostatic hyperplasia（BPH）and plays a pivotal role in its pathogenesis. Ferroptosis may regulate the occurrence and development of BPH by mediating lipid oxidative stress response.