The gut-prostate axis: from microbial dysbiosis to prostatic diseases
10.3760/cma.j.cn112330-20250724-00309
- VernacularTitle:肠-前列腺轴：从微生态失衡到前列腺疾病
- Author:
Jialin MENG
1
;
Chaozhao LIANG
1
Author Information
1. 安徽医科大学第一附属医院泌尿外科 安徽医科大学泌尿外科研究所 安徽省泌尿系统疾病临床医学研究中心，合肥 230022
- Publication Type:Journal Article
- Keywords:
Gut microbiota;
Gut-prostate axis;
Chronic prostatitis;
Benign prostatic hyperplasia;
Prostate cancer
- From:
Chinese Journal of Urology
2025;46(8):576-580
- CountryChina
- Language:Chinese
-
Abstract:
Prostatic diseases are with the high prevalence，significantly impair men’s health and quality of life，yet their pathogenesis remains intricate and multifactorial. In recent years，the gut microbiota has been extensively reported to influence extraintestinal organs through metabolic modulation and immune regulation，leading to the emergence of the “gut-organ axis” as a conceptual framework. We systematically outline the commonly recognized “gut-organ axes，” with a particular focus on recent advances in understanding the “gut-prostate axis” in the context of prostate cancer，benign prostatic hyperplasia，and chronic prostatitis. Drawing on findings from our research group，we propose future directions for the identification of microbial targets，mechanistic exploration，and clinical translation in this emerging field.
