Advances in research on mechanisms underlying damage of low-dose ionizing radiation to spermatogenesis and relevant protective measures
10.3760/cma.j.cn112271-20240924-00378
- VernacularTitle:低剂量电离辐射对精子发生的损伤机制及防护研究进展
- Author:
Shen ZHU
1
;
Bo HU
;
Minghui CUI
;
Haobing YU
;
Xiaoyu LIU
;
Suiyi LIU
;
Ying HE
Author Information
1. 中国人民解放军海军特色医学中心辐射安全与职业健康研究室，上海 200433
- Publication Type:Journal Article
- Keywords:
Low dose of ionizing radiation;
Spermatogenesis;
Reactive oxygen species;
DNA repair;
Radiation protection
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(8):818-826
- CountryChina
- Language:Chinese
-
Abstract:
Ionizing radiation occurs not only during nuclear and radiological terrorist attacks or nuclear accidents but also in medical applications and daily life. In recent years, the potential toxic effects of low-dose ionizing radiation on the male reproductive system have raised public health concerns. Most specifically, for the testis, a highly sensitive target organ to ionizing radiation, there is an urgent need to determine the mechanisms underlying the association between radiation-induced spermatogenic failure and male infertility. Focusing on the potential injurious effects of low-dose ionizing radiation on spermatogenesis, this review presents a summary and analysis of various underlying mechanisms including oxidative stress, apoptosis, and DNA damage repair and reviews recent domestic and international strategies for protecting against radiation-induced reproductive system damage in order to offer references for future research on the injurious effects of low-dose radiation on spermatogenesis and relevant protection.
