Research progress on internal dose estimation mehtods for radionuclide therapy
10.3760/cma.j.cn112271-20250408-00127
- VernacularTitle:放射性核素内照射治疗剂量估算方法研究进展
- Author:
Jiacheng QI
1
;
Weihai ZHUO
1
;
Junhao LI
1
;
Jinghang WANG
1
Author Information
1. 复旦大学放射医学研究所，上海 200032
- Publication Type:Journal Article
- Keywords:
Radionuclide therapy;
In vivo imaging;
Pharmacokinetic model;
Internal radiation dose;
Dose-effect
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(8):810-817
- CountryChina
- Language:Chinese
-
Abstract:
Dose estimation of radiopharmaceutical therapy is essential for the accurate evaluation of its efficacy and safety, as well as for guiding subsequent clinical research. The dosimetry estimation process typically requires understanding of the in vivo spatial distribution and dynamic transportation of radionuclides, followed by calculation of the energy deposition in tumor target volume and organs at risk from ionizing radiation of varying types and energies released by accumulated radionuclides. This review focuses on advancements in the aforementioned research aspects and the relationship between internal radiation dose and biological effects. Furthermore, this review prospectively discusses future research directions, aiming to enhance comprehension of internal radiation dose estimation and provides theoretical frameworks and technical references for improving clinical evaluation accuracy in radiopharmaceutical therapy.
