Advances in lung-related bystander and abscopal effects induced by radiation
10.3760/cma.j.cn112271-20240718-00265
- VernacularTitle:肺相关辐射旁效应与远隔效应的研究进展
- Author:
Xue WU
1
;
De CHANG
Author Information
1. 中国人民解放军总医院第八医学中心呼吸与危重症医学部，北京 100091
- Publication Type:Journal Article
- Keywords:
Radiation-induced bystander effect;
Abscopal effect;
Thoracic radiotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(7):699-705
- CountryChina
- Language:Chinese
-
Abstract:
In the field of radiotherapy, radiation-induced bystander and abscopal effects have attracted increasing attention. Studies indicate that these effects can extend from irradiated regions to non-irradiated cells or tissues. Radiation-induced bystander and abscopal effects related to lung can be categorized into lung-lung type, lung-extrapulmonary tissue type, and extrapulmonary tissue-lung type. The mechanism of its occurrence involves oxidative stress, immune response, and the role of extracellular vesicles. These effects exhibit a dual characteristic of inducing damage to normal tissues and increasing tumor therapeutic potential. Immune responses represent a pivotal mechanism, and the combination of radiotherapy with immunotherapy may enhance the incidence of abscopal effects. Researchers are exploring various intervention strategies to control or utilize these effects. Future studies should further investigate the underlying biological mechanisms, particularly in specific organs or sites, to improve the efficacy and safety of radiotherapy. This review explores the latest advances in lung-related radiation-induced bystander and abscopal effects, encompassing their definitions, classifications, mechanisms, functional characteristics, influencing factors, and intervention strategies.
