Impacts of the radiosensitivity of cell lines on a microdosimetric kinetic model
10.3760/cma.j.cn112271-20240808-00302
- VernacularTitle:细胞系辐射敏感性对微剂量动力学模型的影响研究
- Author:
Honghu SONG
1
;
Zun PIAO
;
Guomin HUANG
;
Jian SHI
;
Ming CHEN
;
Xiaoyan HUANG
Author Information
1. 中山大学肿瘤防治中心，广州 510060
- Publication Type:Journal Article
- Keywords:
Carbon-ion radiotherapy;
Cellular radiosensitivity;
Microdosimetric kinetic model (MKM);
Relative biological effectiveness (RBE)
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(5):416-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the impacts of the radiosensitivity of cell lines on a microdosimetric kinetic model (MKM) used in carbon-ion radiotherapy.Methods:The saturation-corrected specific energy ( ) of monoenergetic carbon ions was calculated using the Kiefer-Chatterjee (K-C) track structure model. Correction curve f(LET) was derived from experimental data on relative biological effectiveness (RBE) (RBE DSB-LET) defined based on the double-strand DNA break of the Chinese hamster ovary (CHO) and Fibroblast cell lines irradiated using carbon ions with varying linear energy transfer (LET) values. Then, based on the MKM, the D10-LET curves, as well as α and β databases, of the CHO and Fibroblast cell lines with varying radiosensitivity were determined. Results:Compared to the clinically applied MKM, the predicted D10 after correction while accounting for cell line radiosensitivity agreed better with experimental D10 values of the CHO and Fibroblast cell lines. Specifically, compared to experimental values in the literature, the D10 values calculated in the study and determined using the MKM showed mean squared errors (MSEs) of 0.04 and 0.71, for the CHO cell line and 0.35 and 0.55, respectively, for the Fibroblast cell line. For monoenergetic carbon ions with varying LET values, the calculated α and β values generally increased with cellular radiosensitivity. Conclusions:Incorporating cellular radiosensitivity into the MKM framework serves as a more specific method for RBE assessment while also providing a reference for advancing MKM applications and achieving the fine-scale calculations of RBE in carbon-ion radiotherapy.
