Advances in research on the role of tRNA-derived fragments in tumor formation and progression and their applications to radiotherapy for tumors
10.3760/cma.j.cn112271-20240512-00172
- VernacularTitle:tRNA衍生片段在肿瘤发生发展中的作用及放疗应用的研究进展
- Author:
Mengdie ZHAO
1
;
Junxuan YI
;
Shunzi JIN
;
Ning WU
Author Information
1. 吉林大学公共卫生学院 国家卫健委放射生物学重点实验室，长春 130021
- Publication Type:Journal Article
- Keywords:
tRF;
Tumor;
Radiotherapy;
Tumor marker
- From:
Chinese Journal of Radiological Medicine and Protection
2025;45(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
tRNA-derived small RNAs (tsRNAs)—small RNA fragments derived from transfer ribonucleic acid (tRNA)—fall into the category of small non-coding RNAs (sncRNAs). They can be categorized into two major types: tRNA-derived fragments (tRFs) and tRNA-derived stress-induced small RNAs (tiRNAs). With the rapid advancement in high-throughput sequencing technologies and bioinformatics, tsRNAs have been involved in a variety of biological processes, including gene expression, signal transduction, and epigenetic inheritance, while also playing a significant role in tumor progression. The efficacy of radiotherapy is primarily affected by radiation-induced damage to normal tissues and the resistance of tumor cells to radiotherapy. It has been found that tsRNAs plays a significant role in radiation-induced cellular damage, as well as the modulation of radiation sensitivity and resistance. This highlights their potential as promising therapeutic targets in radiotherapy for tumors. This study reviews the origins, classification, biological functions of tRFs, as well as the advances in research on their role in tumor formation and progression and their applications in radiotherapy for tumors. This study aims to explore the research value of tRFs and their potential for application in radiotherapy for tumors.
