Effect of transient receptor potential vanilloid type 1 gene polymorphism on postoperative analgesic efficacy of alfentanil in patients undergoing radical mastectomy
10.3760/cma.j.cn131073-20241216-01114
- VernacularTitle:TRPV1基因多态性对乳腺癌根治术患者术后阿芬太尼镇痛效应的影响
- Author:
Liying BAI
1
;
Xinfeng LI
1
;
Lihua YANG
1
Author Information
1. 郑州大学第一附属医院麻醉与围手术期及疼痛医学部，郑州 450052
- Publication Type:Journal Article
- Keywords:
TRPV cation channels;
Polymorphism, single nucleotide;
Breast neoplasms;
Alfentanil;
Analgesia
- From:
Chinese Journal of Anesthesiology
2025;45(11):1461-1464
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of transient receptor potential vanilloid type 1 (TRPV1) gene polymorphism on the postoperative analgesic efficacy of alfentanil in patients undergoing radical mastectomy.Methods:In this prospective study, adult female patients diagnosed with breast cancer who underwent surgical treatment at the First Affiliated Hospital of Zhengzhou University were selected as case group ( n=162), while age-matched healthy adult females were selected as control group ( n=80). All subjects had a body mass index of 18-30 kg/m 2. The genotype and allele frequencies of TRPV1 rs8065080 and rs222747 were compared between the two groups, and the consumption of alfentanil and requirement for rescue analgesia within 48 h after surgery were recorded in breast cancer patients with different TRPV1 rs222747 genotypes. Results:Three genotypes of CC, GC, and GG were detected at rs222747 locus of TRPV1 gene, and there was no significant difference in the genotype distribution between the two groups ( P>0.05). Three genotypes of CC, TC and TT were detected at rs8065080 locus of TRPV1 gene, and there was significant difference in the genotype distribution between the two groups ( P<0.05). There was no significant difference in the basic data of patients with different genotypes of TRPV1 gene rs222747 locus ( P>0.05). There were significant differences in the consumption of alfentanil during 0-24 h after surgery and during 24-48 h after surgery and rate of rescue analgesia within 48 h after surgery among patients with different genotypes of TRPV1 gene rs222747 locus ( P<0.05). Conclusions:The polymorphism at the TRPV1 gene rs222747 locus can influence the postoperative analgesic efficacy of alfentanil in breast cancer patients undergoing radical mastectomy, suggesting that genetic factors may be one of the reasons for the inter-individual variability in alfentanil efficacy.
