Median effective dose of oliceridine inhibiting responses to laryngeal mask airway insertion when combined with ciprofol in elderly patients
10.3760/cma.j.cn131073-20241121-00916
- VernacularTitle:复合环泊酚时奥赛利定抑制老年患者喉罩置入反应的半数有效剂量
- Author:
Di FAN
1
;
Cuina SHI
1
;
Muhuo JI
1
;
Jianhua TONG
1
;
Di WANG
1
Author Information
1. 南京医科大学第二附属医院麻醉科，南京 210009
- Publication Type:Journal Article
- Keywords:
Analgesics, opioid;
Aged;
Dose-response relationship, drug;
Laryngeal masks;
Ciprofol
- From:
Chinese Journal of Anesthesiology
2025;45(9):1172-1175
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the median effective dose (ED 50) of oliceridine inhibiting the responses to the laryngeal mask airway insertion when combined with ciprofol in elderly patients. Methods:In this sequential trial, American Society of Anesthesiologists Physical Status classificationⅠ-Ⅲ elderly patients of either sex, aged ≥65 yr, with a body mass index of 18-30 kg/m 2, undergoing elective urological surgery under general anesthesia with laryngeal mask airway, were included in this study. Ciprofol 0.4 mg/kg was intravenously injected, the dose of oliceridine was determined by using modified Dixon′s up-and-down method (increment or decrement of 0.005 mg/kg), and the initial dose of oliceridine was 0.01 mg/kg. A positive response was defined as an increase in maximum mean arterial pressure or heart rate ≥20% within 3 min after inserting the laryngeal mask airway or occurrence of any one of these signs such as movement, coughing, frowning, mouth corner twitching, tearing, laryngospasm, or bispectral index value failing to drop below 60. The trial was terminated upon observing 7 positive-to-negative transition points, starting from the first occurrence of an alternation between positive and negative responses to laryngeal mask airway insertion. The ED 50 and 95% confidence interval of oliceridine inhibiting the responses to the laryngeal mask airway insertion was calculated when combined with ciprofol in elderly patients. Results:The ED 50 of oliceridine inhibiting the response to laryngeal mask airway insertion was 0.027 mg/kg, and the 95% confidence interval was 0.008-0.048 mg/kg when combined with ciprofol 0.4 mg/kg. Conclusions:The ED 50 of oliceridine inhibiting the response to laryngeal mask airway insertion is 0.027 mg/kg when combined with ciprofol 0.4 mg/kg in elderly patients.
