Trends in incidence and disease burden of hypertensive disorders in pregnancy in China from 1990 to 2021: an analysis based on Global Burden of Disease data
10.3760/cma.j.cn112141-20250526-00233
- VernacularTitle:1990—2021年中国妊娠期高血压疾病发生率及疾病负担趋势
- Author:
Manman CHEN
1
;
Wanzhou WANG
;
Qu LU
;
Jiahui WANG
;
Yuankai ZHAO
;
Yu JIANG
;
Xiaotian LI
;
Qiongjie ZHOU
Author Information
1. 中国医学科学院北京协和医学院群医学及公共卫生学院，北京 100730
- Publication Type:Journal Article
- Keywords:
Incidence;
Global burden of disease;
Data analysis;
Hypertensive disorders in pregnancy
- From:
Chinese Journal of Obstetrics and Gynecology
2025;60(9):723-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the changing trends and international differences in the incidence and disability-adjusted life years (DALY) of hypertensive disorders in pregnancy (HDP) in China from 1990 to 2021 based on the Global Burden of Disease (GBD) database.Methods:The data were derived from the GBD database, covering the incidence and DALY data of HDP in countries or regions around the world. Descriptive statistics were used to compare the differences in disease burden between China and different regions of Europe, America and other developed countries, and to analyze the disease burden characteristics of women of childbearing age in different age groups (every 5 years). The Joinpoint regression model was used to identify trend change points. The age-period-cohort model was used to analyze the independent effects of age, period and birth cohort.Results:(1) From 1990 to 2021, the incidence of HDP in China showed an overall downward trend, from 387.18/100 000 in 1990 to 216.35/100 000 in 2021. Compared with the global incidence rate (1990: 1 167.28/100 000; 2021: 923.48/100 000), the incidence rate of HDP in China was relatively low, but it was still higher than that in some developed countries. (2) The analysis of the Joinpoint regression model showed that the incidence rate of HDP in different age groups first decreased, then increased, and finally leveled off. The connection point with the lowest point was in 2005. DALY showed a continuous downward trend in all age groups. Among them, the decline in maternal DALY of pregnant women in all age groups from 15 to 39 years old was more obvious. (3) The age-period-cohort effect model showed that the incidence rate and DALY of HDP in women of childbearing age aged 20 to 24 years reached their peak.Conclusions:The burden of HDP in China continues to decrease, and the disease prevention and control has achieved remarkable results, but the incidence rate is still higher than that in some developed countries. It is suggested that personalized interventions should be developed for different risk groups to further reduce the burden of disease.
