Research progress of integrated treatment of Chinese and Western medicine of septic acute kidney injury based on"gut-kidney axis"
10.3969/j.issn.1008-9691.2025.03.021
- VernacularTitle:基于"肠-肾轴"理论的脓毒症急性肾损伤中西医结合诊治进展
- Author:
Dongchen GUO
1
;
Meili DUAN
1
Author Information
1. 首都医科大学附属北京友谊医院重症医学科,北京 100050
- Publication Type:Journal Article
- Keywords:
Sepsis;
Septic acute kidney injury;
Gut-kidney axis;
Traditional Chinese medicine
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2025;32(3):364-368
- CountryChina
- Language:Chinese
-
Abstract:
Septic acute kidney injury(SAKI)is an acute renal dysfunction induced by sepsis,characterized by rapid onset,severe condition,and poor prognosis.With high incidence and mortality rates,it remains one of the leading cause of death in critically ill patients.The pathophysiological mechanisms underlying SAKI are multifactorial,involving ischemia,hypoperfusion,immune dysregulation,inflammatory response,microcirculatory disturbances,and mitochondrial dysfunction.Despite extensive research,no specific therapeutic strategies are currently available.In recent years,with the proposal of the"gut-kidney axis"theory,which emphasizes the bidirectional interaction between the gut and kidney,new insights have emerged for the treatment of SAKI.Sepsis leads to intestinal barrier dysfunction and gut microbiota dysbiosis,which exacerbate renal injury through inflammatory mediators and toxins.Conversely,renal dysfunction further disrupts intestinal homeostasis,forming a vicious cycle.In recent years,the integrated approach of combining traditional Chinese medicine(TCM)and Western medicine in the management of SAKI has garnered increasing attention.TCM,which asserts that"the spleen governs transportation and transformation,while the kidney regulate water and fluids"is consistent with the Western conceptualization of the"gut-kidney axis"and its functional regulatory mechanisms.The"simultaneous treatment of the gut and kidney"approach leverages TCM interventions that tonify the spleen and kidney,clear heat,detoxify,and promote bowel movements,in conjunction with Western therapies such as anti-infection treatments and renal replacement strategies,facilitating a multi-target therapeutic paradigm for SAKI.In conclusion,the integration of TCM and Western medicine based on the"gut-kidney axis"theory represents a burgeoning area of research.This combined therapeutic strategy,which targets both the gut and kidneys,demonstrates substantial potential in modulating gut function,promoting renal recovery,and enhancing patient prognosis.
