Research status of reversing chemoresistance of osteosarcoma by traditional Chinese medicine ingredients
10.3781/j.issn.1000-7431.2024.2404-0223
- VernacularTitle:中草药单体逆转骨肉瘤化疗耐药的研究现状
- Author:
Danting XIAO
1
;
Haijun TANG
;
Kai LUO
;
Hongcai TENG
;
Hening LI
;
Wei DAI
;
Yun LIU
Author Information
1. 广西医科大学第一附属医院脊柱骨病外科,广西壮族自治区 南宁 530021
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medicine ingredients;
Osteosarcoma;
Chemoresistance;
Pharmacological effects of traditional Chinese medicine
- From:
Tumor
2025;45(2):170-183
- CountryChina
- Language:Chinese
-
Abstract:
Osteosarcoma is the most common primary malignant bone tumor,typically treated with a combination of surgery and chemotherapy in clinical practice.However,the increasing prevalence of chemotherapy resistance poses a significant challenge.Chemotherapy resistance can lead to a sharp decline in patients'survival rates.Traditional Chinese medicine,known for its low cost,wide-ranging efficacy,and diverse varieties,has attracted significant attention from researchers.Their attempts to investigate the sensitizing effect of extracted ingredients on osteosarcoma chemoresistance both in vitro and in vivo have yielded promising results.This review has summarized the studies of single traditional Chinese medicine ingredients on reversing osteosarcoma chemoresistance by the mechanisms of chemoresistance,and found that the current research of the clinical mechanism of traditional Chinese medicine ingredients in reversing osteosarcoma chemoresistance is still lacking,indicating significant potential for future development.Utilizing the theory of herbal medicine properties as the theoretical basis for ingredient development may provide novel strategies for the development of new therapeutic approaches.
