Microsatellite instability-high metastatic gastric cancer treated with immunotherapy combined with chemotherapy:A case report and literature review
10.3781/j.issn.1000-7431.2025.2306-0314
- VernacularTitle:免疫治疗联合化疗治疗微卫星高度不稳定型转移性胃癌:1例报告及文献复习
- Author:
Zhihong XU
1
;
Qian ZHANG
1
;
Hui JIN
1
Author Information
1. 河北医科大学第四医院肿瘤内科,河北 石家庄 050000
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
Microsatellite instability-high;
Immunotherapy;
Chemotherapy;
Tumor microenvironment
- From:
Tumor
2025;45(2):137-141
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the malignant tumors with strong invasion and heterogeneity.Individualized treatment of gastric cancer based on precise classification guidance is currently a research hotspot.Microsatellite instability-high(MSI-H)gastric cancer has specific clinical features,tumor microenvironment,and pathological characteristics,which have been used as tumor markers to evaluate the prognosis of gastric cancer patients.In recent years,immunotherapy has brought new hope for the treatment of gastric cancer patients,among whom MSI-H patients are considered the advantageous population for immunotherapy.This paper reports a case of MSI-H metastatic gastric cancer receiving immunotherapy combined with chemotherapy,and provides reference for clinical practice based on literature review.
