Effect of age factor on sedative potency of ciprofol
10.3760/cma.j.cn131073-20250109-00917
- VernacularTitle:年龄因素对环泊酚镇静效力的影响
- Author:
Jinhu XUE
1
;
Long HE
1
;
Zhongyu WANG
1
Author Information
1. 郑州大学第一附属医院麻醉与围术期医学及疼痛医学部，郑州 450002
- Publication Type:Journal Article
- Keywords:
Age factors;
Dose-response relationship, drug;
Ciprofol;
Sedation
- From:
Chinese Journal of Anesthesiology
2025;45(9):1176-1178
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of age factor on the sedative potency of ciprofol.Methods:In this prospective study, patients of either sex, aged 40-80 yr, undergoing elective surgery under general anesthesia at the First Affiliated Hospital of Zhengzhou University, were selected and divided into middle-aged group (40-<65 yr) and elderly group (65-80 yr) based on their age. Effective sedation was defined as the Modified Observer′s Assessment of Alertness/Sedation scale score ≤1 and the bispectral index value ≤60 within 3 min following ciprofol administration. The initial dose of ciprofol was 0.4 mg/kg. The dose of ciprofol was determined by using the modified Dixon′s up-and-down method (increment or decrement of 0.04 mg/kg). The experiment was terminated after observing 8 transitions from effective sedation to ineffective sedation, starting from the initial transition event. The probit method was used to determine the median effective dose (ED 50) and 95% confidence interval of ciprofol for sedation. Results:A total of 61 patients was finally included in this study, with 35 in middle-aged group and 26 in elderly group. The ED 50 of ciprofol (95% confidence interval) was 0.296 (0.206-0.359) mg/kg in middle-aged group and 0.224 (0.185-0.257) mg/kg in elderly group. The ED 50 of ciprofol was significantly higher in middle-aged group than in elderly group ( u=181.00, P<0.001). Conclusions:Age can affect the sedative potency of propofol, with enhanced potency observed in elderly patients than in middle-aged patients.
