Optimization effects of ciprofol-based intravenous anesthesia for retroperitoneal laparoscopic radical nephrectomy in elderly patients: a prospective randomized controlled study
10.3760/cma.j.cn131073-20240720-00612
- VernacularTitle:环泊酚静脉复合麻醉用于后腹腔镜肾癌根治术老年患者的优化效果：前瞻性随机对照研究
- Author:
Yilong GAO
1
;
Yaqing ZHANG
;
Tengchen FENG
;
Jingui GAO
;
Xiang LI
Author Information
1. 四川大学华西医院泌尿外科，成都 610041
- Publication Type:Journal Article
- Keywords:
Aged;
Laparoscopy;
Nephrectomy;
Hemodynamics;
Patient outcome evaluation;
Anesthesia, intravenous;
Propofol;
Ciprofol
- From:
Chinese Journal of Anesthesiology
2025;45(6):732-735
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the optimization effects of ciprofol-based intravenous anesthesia in elderly patients undergoing retroperitoneal laparoscopic radical nephrectomy.Methods:This study was a prospective randomized controlled study. Eighty elderly patients scheduled for elective retroperitoneal laparoscopic radical nephrectomy were randomized to receive either ciprofol-based (group C) or propofol-based intravenous anesthesia (P group), with 40 patients in each group. Anesthesia was induced by intravenous injection of ciprofol 0.4 mg/kg and maintained by intravenous infusion of ciprofol and remifentanil during operation in group C. In group P, anesthesia was induced by intravenous injection of propofol 1.5 mg/kg and maintained by intravenous infusion of propofol and remifentanil during operation. The onset time of sedative effect following anesthesia induction, hypotension and injection pain during induction and intraoperative hypotension were recorded.Results:Compared to P group, the incidence of hypotension and injection pain during induction was significantly decreased (28% vs 10%, 60% vs 18%, P<0.05); although the difference in the incidence of intraoperative hypotension was not statistically significant (25% vs 15%, P>0.05), the RR was 0.6; no significant change was found in the onset time of sedative effect following anesthesia induction in C group ( P>0.05). Conclusions:Compared to propofol-based intravenous anesthesia, ciprofol-based intravenous anesthesia has certain optimization effects in elderly patients undergoing retroperitoneal laparoscopic radical nephrectomy.
