The role of energy metabolism control in immune regulation after liver transplantation for hepatocellular carcinoma
10.3781/j.issn.1000-7431.2025.2405-0293
- VernacularTitle:控制能量代谢在肝癌肝移植术后免疫调控中的作用
- Author:
Linna GAO
1
;
Yangyang TANG
1
;
Yifan LIU
1
;
Tonghai XING
1
Author Information
1. 上海交通大学医学院附属上海市第一人民医院普外科,上海 200080
- Publication Type:Journal Article
- Keywords:
Liver cancer;
Liver transplantation;
Energy metabolism;
Immunomodulation
- From:
Tumor
2025;45(2):142-150
- CountryChina
- Language:Chinese
-
Abstract:
Liver cancer stands as one of the most lethal malignant tumors globally,and liver transplantation presents a potent and effective therapeutic approach for affected individuals.However,the post-transplantation immune regulation is critical for the survival of the graft and the long-term prognosis of the patient.Energy metabolism plays a pivotal role in both the tumor microenvironment and immunomodulation following liver transplantation.This review explores the metabolic mechanisms within the tumor microenvironment,energy metabolism characteristics in liver transplantation,and the impact of post-transplantation energy metabolism on reducing liver cancer recurrence and mitigating transplant rejection.By gaining an in-depth comprehension of the intricate interplay between metabolic pathways and immune regulation,it is envisioned that innovative therapeutic strategies can be formulated.These strategies aim to enhance the outcomes for liver transplant recipients and offer more efficacious treatment options for those afflicted with liver cancer.
