Effect of remimazolam tosilate on postoperative delirium in elderly patients undergoing urological surgery
10.3760/cma.j.cn131073-20241114-00804
- VernacularTitle:甲苯磺酸瑞马唑仑对泌尿外科手术老年患者术后谵妄的影响
- Author:
Yuqing LIU
1
;
Fangfang LI
1
;
Linxin WANG
1
;
Su LIU
1
;
Guanglei WANG
1
Author Information
1. 徐州医科大学附属医院麻醉科，徐州 221006
- Publication Type:Journal Article
- Keywords:
Benzodiazepines;
Urologic surgical procedures;
Aged;
Delirious speech;
Postoperative complications
- From:
Chinese Journal of Anesthesiology
2025;45(8):937-941
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of remimazolam tosilate on postoperative delirium (POD) in elderly patients undergoing urological surgery.Methods:In this randomized controlled trial, 220 American Society of Anesthesiologists Physical Status classification Ⅰ-Ⅲ elderly patients of either sex, aged≥65 yr, with body mass index of 18-28 kg/m 2, scheduled for elective urological surgery under general anesthesia, were divided into 2 groups ( n=110 each) using a random number table method: propofol group (group P) and remimazolam tosilate group (group R). Group P received propofol 1.0-1.5 mg/kg for induction and propofol 2-6 mg·kg -1·h -1 for maintenance, while group R received remimazolam tosilate 0.2-0.3 mg/kg for induction and remimazolam tosilate 0.5-1.2 mg·kg -1·h -1 for maintenance. The other drugs for induction and maintenance were the same in the two groups. POD was assessed using the Chinese version of the 3-minute diagnostic interview for Confusion Assessment Method within 3 days after surgery in the two groups. The intraoperative consumption of remifentanil and usage of vasoactive drugs, extubation time, 15-item Quality-of-Recovery scale scores at 24 h after operation, requirement for rescue analgesia within 24 h after operation, and postoperative adverse effects were recorded. Results:There were no significant differences in the incidence of POD within 3 days after operation, 15-item Quality-of-Recovery scale scores at 24 h after operation, or rate of rescue analgesia within 24 h after operation between two groups ( P>0.05). Compared with group P, the requirement for intraoperative vasoactive drugs was significantly reduced, the extubation time was shortened, and the incidence of hypoxemia was decreased within 24 h after operation in group R ( P<0.05 or 0.001). Conclusions:Remimazolam tosilate has no marked effect on the occurrence of POD in elderly patients undergoing urological surgery.
