Tacrolimus treatment in children with refractory nephrotic syndrome
10.3760/cma.j.cn441217-20240919-00933
- VernacularTitle:他克莫司在儿童难治性肾病综合征中的应用
- Author:
Pei ZHANG
1
;
Chunlin GAO
;
Jiuyu LIU
;
Chenxi MA
;
Mengzhen FU
;
Kaili SHI
;
Qianhuining KUANG
;
Zhengkun XIA
Author Information
1. 南京大学医学院附属金陵医院儿科，南京 210002
- Publication Type:Journal Article
- Keywords:
Child;
Therapy;
Immunosuppressive agents;
Nephrotic syndrome;
Tacrolimus;
Refractory nephrotic syndrome
- From:
Chinese Journal of Nephrology
2025;41(11):901-907
- CountryChina
- Language:Chinese
-
Abstract:
Tacrolimus is an immunosuppressant that was clinically used for organ transplantation in the 1990s. In the early 2000s, tacrolimus began to be used to treat pediatric kidney diseases in China. This article reviews the therapeutic effects, clinical dosages, and treatment methods of tacrolimus in the treatment of steroid-resistant, steroid-dependent, frequently relapsing, different pathological types, and monogenic mutation-related childhood nephrotic syndrome. It explores the clinical guiding role of machine learning in tacrolimus treatment for childhood nephrotic syndrome, aiming to provide references for the clinical research and application of tacrolimus in pediatric kidney diseases.
