Effect of ciprofol on intraoperative hypotension in patients undergoing bronchoscopy procedures
10.3760/cma.j.cn131073-20240826-00405
- VernacularTitle:环泊酚对支气管镜手术患者术中低血压的影响
- Author:
Xiaoyun CHEN
1
;
Wei DU
;
Yanrong LI
;
Dongliang MU
;
Ting DING
Author Information
1. 北京大学第一医院麻醉科，北京 100034
- Publication Type:Journal Article
- Keywords:
Bronchoscopy;
Hypotension;
Ciprofol
- From:
Chinese Journal of Anesthesiology
2025;45(4):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of ciprofol on intraoperative hypotension in patients undergoing bronchoscopy procedures.Methods:In this randomized controlled study, 112 adult patients of either sex, aged 18-64 yr, with a body mass index of 19.8-28.3 kg/m 2, of American Society of Anesthesiologists Physical Status classification Ⅱ or Ⅲ, with estimated operation time of ≥1 h, undergoing elective bronchoscopy procedures, were assigned to one of two groups ( n=56 each) using a random number table method: ciprofol group (C group) and propofol group (P group). All the patients received total intravenous anesthesia. The induction dose of ciprofol was 0.1-0.3 mg/kg, and the maintenance dose was 0.4-1.2 mg·kg -1·h -1 in group C. The induction dose of propofol was 1-3 mg/kg, and the maintenance dose was 4-12 mg·kg -1·h -1 in group P. The primary outcome was the incidence of intraoperative hypotension, and the secondary outcomes were the time of emergence from anesthesia, sleep quality, patients′ and surgeons′ satisfaction with anesthesia, and the incidence of complications within 30 days after surgery. Results:Compared with group P, the incidence of intraoperative hypotension was significantly decreased, and the time of emergence from anesthesia was shortened in group C ( P<0.05). There was no statistically significant difference in secondary outcomes between the two groups ( P>0.05). Conclusions:Ciprofol is superior to propofol in reducing the risk of intraoperative hypotension and facilitates a more rapid emergence from anesthesia in patients undergoing bronchoscopy procedures.
