Correlation analysis between the relative quantification of miR-200a in peritoneal dialysis effluent and peritoneal function in peritoneal dialysis patients
10.3760/cma.j.cn441217-20250206-00207
- VernacularTitle:腹膜透析滤出液中miR-200a相对水平与腹膜透析患者腹膜功能的相关性分析
- Author:
Hui YE
1
;
Jiao HUANG
1
;
Caixia YAN
1
;
Siyu LI
1
;
Jiaming JIANG
1
;
Xiaojiang ZHAN
1
;
Xin WEI
1
Author Information
1. 南昌大学第一附属医院肾内科，南昌 330000
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
Peritoneal fibrosis;
MicroRNA;
Peritoneal function;
miRNA-200a
- From:
Chinese Journal of Nephrology
2025;41(11):859-863
- CountryChina
- Language:Chinese
-
Abstract:
This study was a single-center retrospective study, to investigate the correlation between the relative level of miR-200a in exfoliated cells of peritoneal dialysis (PD) effluent and clinical indicators of peritoneal function in PD patients. Clinical data of PD patients who underwent treatment in the Department of Nephrology, the First Affiliated Hospital of Nanchang University, from January 2024 to December 2024 were collected, and the relative level of miR-200a in exfoliated cells of PD effluent was assessed. Patients were divided into three groups according to dialysis duration (Group A:≤1 year; Group B:>1 to <5 years; Group C:≥5 years), and differences in clinical data among the groups were compared. The correlation between the relative level of miR-200a and serum albumin, serum calcium, serum phosphorus, serum creatinine, hemoglobin, the neutrophil/high-density lipoprotein cholesterol ratio, the monocyte/high-density lipoprotein cholesterol ratio, the lymphocyte/high-density lipoprotein cholesterol ratio, and 24-hour urine volume in PD patients was analyzed. The results showed that there were no statistically significant differences among the three groups in gender, age, creatinine clearance rate, or Kt/V (all P>0.05). However, statistically significant differences were found among the three groups in peritoneal transport type ( χ2=13.518, P=0.001) and ultrafiltration volume ( H=6.905, P=0.032). Based on the 4-hour PD effluent creatinine/blood creatinine in the peritoneal equilibration test, patients were divided into the low transporter/low average transporter group (L group) and the high transporter/high average transporter group (H group). A statistically significant difference in the relative level of miR-200a was observed between the two groups [11.70 (1.09, 20.49) vs. 0.73 (0.46, 1.98), t=4.545, P<0.001]. The relative level of miR-200a was positively correlated with ultrafiltration volume and 24-hour urine output ( r=0.328, P=0.030; r=0.516, P<0.001), and negatively correlated with dialysis vintage ( r=-0.496, P<0.001). These results indicate that miR-200a level in PD effluent may, to some extent, reflect patients' peritoneal membrane function.
