Farnesoid X receptor: a novel target for renal immune regulation
10.3760/cma.j.cn441217-20240918-00930
- VernacularTitle:法尼酯X受体：肾脏免疫调节的新靶标
- Author:
Caiqian WU
1
;
Chengguo LYU
;
Qianrui MI
;
Guojing ZHANG
;
Ling LI
;
Qifa YE
Author Information
1. 武汉大学中南医院肝胆疾病研究院 武汉大学移植医学中心 国家人体捐献器官获取质量控制中心 移植医学技术湖北省重点实验室，武汉 430071
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Immunomodulation;
Drug development;
Farnesoid X receptor
- From:
Chinese Journal of Nephrology
2025;41(10):782-787
- CountryChina
- Language:Chinese
-
Abstract:
Immune-related kidney disease is one of the causes of end-stage renal disease and an important disease type that threatens public health. Farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids, involved in regulating gene expression related to bile acid, lipid, and glucose metabolism. In recent years, the role of FXR in renal immune regulation has received attention. FXR participates in the occurrence and development of immune-related kidney diseases by regulating the differentiation, polarization, activation, recruitment, adhesion, infiltration, and cytokine release of immune cells such as macrophages, dendritic cells, natural killer cells, T lymphocytes, and B lymphocytes. This article reviews renal immune-regulatory mechanisms of FXR in recent years and its potential role in immune-related kidney diseases, to provide a theoretical basis for the prevention and treatment of immune-related kidney diseases targeting FXR.
