Effect of degree of neuromuscular block on intraoperative surgical conditions and postoperative recovery quality in patients undergoing lumbar interbody fusion
10.3760/cma.j.cn131073-20241030-00411
- VernacularTitle:肌松程度对腰椎椎间融合术患者术中手术条件及术后恢复质量的影响
- Author:
Jie GUO
1
;
Xiaoyi CHEN
;
Junda CHEN
;
Xinghe WANG
;
Dong HUANG
;
Dongmei YUE
;
Linlin ZHAO
;
Junli CAO
;
Su LIU
Author Information
1. 徐州医科大学江苏省麻醉学重点实验室，徐州 221004
- Publication Type:Journal Article
- Keywords:
Neuromuscular blockade;
Lumbar vertebrae;
Spinal fusion;
Rehabilitation;
Surgical conditions
- From:
Chinese Journal of Anesthesiology
2025;45(4):444-448
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of the degree of neuromuscular blockade on the intraoperative surgical conditions and postoperative recovery quality in patients undergoing lumbar interbody fusion.Methods:In this randomized controlled trial, 100 patients of either sex, aged 18-79 yr, with a body mass index of 18.5-35.0 kg/m 2, of American Society of Anesthesiologists Physical Status classification < Ⅳ, scheduled for elective lumbar interbody fusion at the Affiliated Hospital of Xuzhou Medical University from August to October 2024, were allocated into 2 groups ( n=50 each) using stratified randomization based on the number of lumbar segments: deep neuromuscular blockade group (group D) and moderate neuromuscular blockade group (group M). The intraoperative post-tetanic count was maintained at 1 or 2 in group D, and the intraoperative train-of-four was maintained at 1 or 2 in group M. The scores for surgical conditions, duration of operation, blood loss, length of incision, occurrence of severe hypoxemia after extubation, requirement for rescue analgesia in post-anesthesia care unit, 15-item Quality of Recovery scale score and length of stay were recorded. Results:Compared with group M, the scores for surgical conditions were significantly increased, the rate of rescue analgesia in post-anesthesia care unit was decreased, 15-item Quality of Recovery scale scores were increased at 3 days after surgery ( P<0.05), and no significant changes were found in the duration of operation, blood loss, length of incision, incidence of severe hypoxemia after extubation and length of hospital stay in group D ( P>0.05). Conclusions:Compared with moderate neuromuscular blockade, deep neuromuscular blockade can provide better surgical conditions and improve the quality of early postoperative recovery for patients undergoing lumbar interbody fusion.
