Median effective dose of oliceridine inhibiting responses to insertion of gastroscope when combined with propofol in obese patients
10.3760/cma.j.cn131073-20240715-00213
- VernacularTitle:复合丙泊酚时奥赛利定抑制肥胖患者胃镜置入反应的半数有效剂量
- Author:
Jia JIA
1
;
Guoshuang LI
;
Yixuan LI
;
Beibei ZHANG
;
Wei ZHANG
;
Jiaqiang ZHANG
Author Information
1. 河南省人民医院（郑州大学人民医院）麻醉与围术期医学科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Analgesics, opioid;
Propofol;
Obesity;
Oliceridine;
Gastroscope;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2025;45(2):194-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the median effective dose (ED 50) of oliceridine inhibiting responses to insertion of the gastroscope when combined with propofol in obese patients. Methods:In this prospective study, American Society of Anesthesiologists Physical Status classification I or Ⅱ patients of either sex, with a body mass index of ≥28 kg/m 2, undergoing elective painless gastroscopy, were selected. Propofol 1.5 mg/kg was slowly injected intravenously 2 min after intravenous injection of oliceridine. Gastroscopy was performed after the patient′s eyelash reflex disappeared and the jaw was relaxed. The optimal dose was determined by modified Dixon′s up and down method. The initial dose of oliceridine was 0.015 mg/kg, and the ratio between the two successive concentrations was 1.0∶1.2. If the patient had a positive response that affected the examination operation such as swallowing, bucking and body movement during insertion of the gastroscope, the next patient received a higher dose, or conversely if negative, a lower dose was given in the next patient. This process was repeated until the 7th turning point occurred. The ED 50 and 95% confidence interval of olicerdine inhibiting responses to insertion of the gastroscope were calculated by probit method. Results:A total of 21 patients were included in this study, the ED 50 of olicerdine inhibiting responses to implantation of the gastroscope was 0.016 mg/kg, and the 95% confidence interval was 0.010-0.023 mg/kg when combined with propofol 1.5 mg/kg in obese patients. One patient developed hypoxemia. One patient had mild dizziness after operation. Conclusions:The ED 50 of olicerdine inhibiting responses to implantation of the gastroscope is 0.016 mg/kg when combined with propofol 1.5 mg/kg in obese patients.
