Changes in cortical electroencephalogram BSR during sevoflurane anesthesia and correlation with cerebral blood perfusion in septic mice
10.3760/cma.j.cn131073-20240822-00409
- VernacularTitle:脓毒症小鼠七氟烷麻醉时皮层脑电图BSR的变化及其与脑血流灌注的相关性
- Author:
Yun LI
1
;
Lina ZHAO
;
Siwen LONG
;
Yize LI
;
Keliang XIE
;
Yuechun LU
;
Yonghao YU
Author Information
1. 天津医科大学第二医院麻醉科，天津 300211
- Publication Type:Journal Article
- Keywords:
Sepsis;
Sevoflurane;
Electroencephalography;
Cerebrovascular circulation;
Cerebral cortex
- From:
Chinese Journal of Anesthesiology
2025;45(4):433-437
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the changes in cortical electroencephalogram (EEG) burst suppression rate (BSR) during sevoflurane anesthesia in septic mice and the correlation with cerebral blood perfusion.Methods:Forty SPF male C57BL/6J mice, aged 8-10 weeks, weighing 22-25 g, were divided into 2 groups ( n=20 each) by the random number table method: sham operation group (Sham group) and cecal ligation perforation group (CLP group). The sepsis model was established by cecal ligation and puncture in anesthetized animals. Mice in both groups inhaled 2% sevoflurane for 2 h. During sevoflurane anesthesia, BSR (30 min as an epoch) on electroencephalogram was recorded, and the cortical cerebral blood perfusion was recorded using the laser speckle flow imaging at 30, 60, 90 and 120 min of anesthesia. Results:Compared with Sham group, the cortical EEG BSR was significantly increased, and the cortical cerebral blood perfusion was decreased during sevoflurane anesthesia in CLP group ( P<0.05). Cortical EEG BSR was negatively correlated with cortical cerebral blood perfusion ( P<0.05). Conclusions:Cortical EEG BSR increases during sevoflurane anesthesia in septic mice, which may be related to decreased cortical cerebral blood perfusion.
