Association between septic shock and tracheal injury in intensive care unit patients with invasive ventilation: a single-centre prospective cohort study
10.3760/cma.j.cn131073.20240829.01221
- VernacularTitle:重症监护病房有创通气患者脓毒症休克与气管损伤的关系：一项单中心前瞻性队列研究
- Author:
Pei ZHANG
1
;
Qilin YANG
;
Chunhua YIN
;
Zhigang CAI
;
Huaihai LU
;
Haitao LI
;
Liwen LI
;
Ye TIAN
;
Long BAI
;
Lining HUANG
Author Information
1. 河北医科大学第二医院麻醉重症医学科，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Shock, septic;
Critical care;
Respiration, artificial;
Tracheal intubation complication
- From:
Chinese Journal of Anesthesiology
2024;44(12):1505-1513
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between septic shock and tracheal injury in the intensive care unit (ICU) patients with invasive ventilation.Methods:This was a prospective single-centre cohort study. Patients who underwent invasive mechanical ventilation at the Department of Anesthesia Critical Care Medicine of the Second Hospital of Hebei Medical University from May 31, 2020 to March 5, 2022 were selected. The general characteristics of patients, reasons for ICU admission, vital signs, laboratory test results, Acute Physiology and Chronic Health Evaluation Ⅱ scores, Charlson Comorbidity Index, size of endotracheal tube, presence or absence of septic shock, oxygenation index, duration of intubation, consumption of norepinephrine and epinephrine, and tracheal injury scores at the time of extubation were recorded. Univariate linear regression analysis was used to identify the risk factors for tracheal injury, followed by adjustment using multivariate linear regression analysis.Results:Ninety-seven patients were ultimately included, and the average age was (56.6±16.5) yr, with 64.9% being male. The results of adjusted linear regression showed that septic shock was associated with tracheal injury scores ( β=2.99, 95% confidence interval 0.70-5.29). Subgroup analysis revealed a stronger correlation with a duration of intubation≥8 days ( P=0.013). Conclusions:Patients with septic shock exhibit significantly higher tracheal injury scores compared with those without septic shock, suggesting that septic shock may serve as an independent risk factor for tracheal injury.
