Research progress of humanized animal models of IgA nephropathy
10.3760/cma.j.cn441217-20240407-00411
- VernacularTitle:IgA肾病人源化动物模型的研究进展
- Author:
Xiaomin SONG
1
;
Jingsai ZHANG
;
Yanbing LIU
;
Yanhong YUAN
Author Information
1. 青岛大学医学部临床医学系，青岛 266071
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis, IgA;
Disease models, animal;
Mice, transgenic;
Mechanisms
- From:
Chinese Journal of Nephrology
2025;41(8):628-635
- CountryChina
- Language:Chinese
-
Abstract:
IgA nephropathy (IgAN) is the most common primary glomerulonephritis. Mesangial hyperplasia and deposition of IgA immune complex are typical pathological changes of IgAN. Animal model is an important tool to explore the pathogenesis, diagnosis and treatment plan, and evaluate the safety and efficacy of drugs. At present, there are many kinds of IgAN animal models, including humanized animal models and non-humanized animal models, and there are great differences in the modeling principle, method, time and pathological changes. The humanized animal model is closer to the pathogenesis of IgAN in humans and has gradually become a research hotspot. In this paper, common animal models of IgAN in detail from the aspects of modeling method and time, characteristics and significance of each model, and the research progress of anthropomorphic animal models are reviewed to provide reference and inspiration for the basic research of IgAN.
