Effect of esketamine on quality of postoperative sleep in preschool children undergoing day surgery
10.3760/cma.j.cn131073-20240916-00504
- VernacularTitle:艾司氯胺酮对日间手术学龄前患儿术后睡眠质量的影响
- Author:
Yanyun ZHANG
1
;
Zhentao SUN
1
;
Ping LIU
1
Author Information
1. 郑州大学第一附属医院麻醉与围手术期及疼痛医学部，郑州 450000
- Publication Type:Journal Article
- Keywords:
Ketamine;
Sleep;
Child, preschool;
Day surgery
- From:
Chinese Journal of Anesthesiology
2025;45(5):542-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of esketamine on the quality of postoperative sleep in preschool children undergoing day surgery.Methods:This was a prospective randomized controlled study. One hundred and four preschool children of either sex, aged 4-7 yr, of American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ, underwent elective day surgery for strabismus correction under general anesthesia at the First Affiliated Hospital of Zhengzhou University from July to September 2024, were selected. The preschool children were divided into 2 groups ( n=52 each) by the random number table method: control group (group C) and esketamine group (group S). In group S, additional esketamine 0.25 mg/kg was intravenously injected during anesthesia induction. The sleep quality scores were evaluated using the Children′s Sleep Habit Questionnaire by the guardians on the night before surgery, the 1st night after surgery, the 3rd night after surgery and the 7th night after surgery, and development of postoperative sleep disorders (the Children′s Sleep Habit Questionnaire score >41) was recorded. The FLACC pain scores and usage rate of flurbiprofen axetil were recorded immediately before leaving the postanesthesia care unit (PACU) and on days 1, 3 and 7 after surgery. The time of laryngeal mask airway removal, length of stay in PACU and development of adverse reactions such as increased oral secretions, agitation, nausea and delirium within 48 h after surgery were recorded. Results:Compared with group C, the Children′s Sleep Habits Questionnaire score and incidence of postopoerative sleep disorders were significantly decreased on the 1st night after surgery, the FLACC pain scores were decreased immediately before discharge from the PACU and at 1 day after surgery, the usage rate of flurbiprofen axetil was decreased ( P<0.05), and no significant change was found in the time of laryngeal mask airway removal, length of stay in PACU and incidence of postoperative adverse reactions in group S ( P>0.05). Conclusions:Anesthesia induction with esketamine 0.25 mg/kg can improve the quality of postoperative sleep in preschool children undergoing day surgery.
