Investigation and analysis on hepatitis B serum epidemiology and genotyping in Jilin province in 2024
10.3760/cma.j.cn112866-20250604-00114
- VernacularTitle:2024年吉林省乙型肝炎病毒血清流行病学及基因分型研究
- Author:
Simei FU
1
;
Bonan CAO
1
;
Xiang LI
1
;
Leilei WEI
1
;
Shuang WANG
1
Author Information
1. 吉林省疾病预防控制中心（吉林省预防医学科学院）免疫规划指导所 吉林省卫生病毒重点实验室，长春 130062
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Hepatitis B virus;
Serum epidemiology investigation;
Genotyping
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(4):461-467
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess the epidemic characteristics of serum of viral hepatitis B infection ranging in age from 1 to 69 years old in Jilin province in 2024. The genotypes of hepatitis B virus-infected individuals were determined.Methods:In 2024，2 313 people ranging in age from 1 to 69 years old in Jilin province were selected by using multi-stage random sampling method for field epidemiological investigation of hepatitis B. The serum samples were collected and detected for the hepatitis B virus（HBV）surface antigen（HBsAg），HBV surface antibody（HBsAb），HBV core antibody（HBcAb），HBV E antigen（HBeAg）and HBV E antibody（HBeAb）by ELISA，and the data were analyzed by the national epidemiological dynamic data collection platform，SPSS 18.0 software. Genotyping is conducted based on the internationally recognized large S region gene fragment.Results:The vaccination rates for hepatitis B among people aged 1-4，5-14，15-29 and 30-69 were 97.00%，94.66%，74.59% and 2.88%，respectively. There were significant differences in hepatitis B vaccination rates across age groups surveyed in 2024（ χ2=1 041.41， P<0.05）. In 2024，the HBsAg carrying rate，HBsAb positive rate，HBV infection rate，HBeAb positive rate and HBeAg positive rate of people in Jilin province were 0. 86%，47.99%，2.25%，5.58% and 5.14%，respectively. The genotype of hepatitis B virus in the infected person is B2 and C2. Conclusions:In 2024，the indicators of HBV infection in Jilin province were good. The highest rate of hepatitis B infection was 11.54% in people with 30-69 years of age and the high vaccination rate of people should continue to be maintained，and the vaccination of hepatitis B vaccine for adults should be strengthened to reduce the risk of infection in these susceptible groups.
