Analysis of survival time and influencing factors of 1411 HIV/AIDS cases in Yancheng city，Jiangsu province from 2016 to 2020
10.3760/cma.j.cn112866-20250729-00163
- VernacularTitle:2016—2020年江苏省盐城市1 411例HIV/AIDS生存时间及影响因素分析
- Author:
Yi CAO
1
;
Yu YAN
;
Guoyan JIANG
;
Lei ZOU
;
Yao QI
Author Information
1. 盐城市疾病预防控制中心 公共卫生分子生物学重点实验室，盐城 224000
- Publication Type:Journal Article
- Keywords:
HIV/AIDS;
Survival time;
Influencing factors;
Cox proportional hazards regression
- From:
Chinese Journal of Experimental and Clinical Virology
2025;39(5):575-581
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the survival time and influencing factors of human immunodeficiency virus（HIV）infected individuals and acquired immunodeficiency syndrome（AIDS）patients in Yancheng City from 2016 to 2020.Methods:The survival and death information of HIV/AIDS patients in Yancheng city from 2016 to 2020 was collected through the National AIDS Comprehensive Prevention and Control Information System. A retrospective cohort study was conducted，and the survival status of HIV/AIDS patients was analyzed using life tables. The Cox proportional hazards regression model was used to analyze the influencing factors of survival time.Results:A total of 1 411 HIV/AIDS patients were included in this study. By the end of the study，the cumulative survival rates of patients at 1-5 years were 93.90%，91.95%，91.24%，90.35%，and 90.12%，respectively. The multivariate Cox proportional hazards model analysis results showed that the risk of death for the age group of ≥60 years at the first diagnosis of HIV positive was 1.54 times that of the <45 years age group（95% CI：1.05-2.28）；the risk of death for the CD4 +T lymphocyte（CD4）count groups of 200-349 cells/μl，350-499 cells/μl，and ≥500 cells/μl was 0.30 times（95% CI：0.19-0.47），0.21 times（95% CI：0.11-0.42），and 0.12 times（95% CI：0.04-0.37）that of the <200 cells/μl group，respectively；the risk of death for those who received antiviral treatment was 0.08 times（95% CI：0.05-0.12）that of those who did not receive antiviral treatment；and the risk of death from HIV/AIDS for cases detected through medical institution testing is 2.23 times（95% CI：1.14-3.51）that of cases detected through testing and counseling. Conclusion:The study of HIV/AIDS in Yancheng city from 2016 to 2020 shows that older age at diagnosis，lower initial CD4 +T lymphocyte count，no antiviral treatment，and detection by medical institutions are associated with higher risk of death. It is recommended to expand testing，improve treatment compliance，and promote early detection and treatment of high-risk groups to prolong survival.
