Effects of different doses of sufentanil on pupillary dilation reflex during induction of general anesthesia
10.3760/cma.j.cn131073-20250121-00714
- VernacularTitle:不同剂量舒芬太尼对全身麻醉诱导期患者瞳孔扩张反射的影响
- Author:
Liji XING
1
;
Jiang ZHU
1
;
Xuelan ZHOU
1
;
Hairui LIU
1
;
Hong XIE
1
Author Information
1. 苏州大学附属第二医院麻醉科，苏州 215004
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Anesthesia, general;
Reflex, pupillary
- From:
Chinese Journal of Anesthesiology
2025;45(7):857-860
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effects of different doses of sufentanil on the pupillary dilation reflex (PDR) during induction of general anesthesia.Methods:In this randomized controlled study, 124 patients of either sex, aged 18-64 yr, with a body mass index of 18-30 kg/m 2, of American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ, undergoing surgery with general anesthesia, were divided into 4 groups ( n=31 each) using a random number table method: control group (group C) and different doses of sufentanil groups (S1-S3 groups). Sufentanil 0.2, 0.4 and 0.6 μg/kg were intravenously injected in S1-S3 groups, respectively, and the equal volume of normal saline was injected instead in group C. Tetanic stimulation (50 mA, 50 Hz, 5 s) was applied at 5 min after injection of sufentanil. Pupil diameter was measured and the pupillary dilation value and dilation rate were calculated upon entering the operating room while awake, after loss of consciousness, 5 min after intravenous injection of sufentanil, and at maximal pupil diameter after tetanic stimulation. The presence or absence of PDR, PDR latency and PDR duration were also recorded. Results:The pupillary dilation values and dilation rates decreased progressively from group C through groups S1 to S3 ( P<0.05). Compared to group C, the disappearance rate of PDR was significantly increased, and the latency of PDR was prolonged in groups S2 and S3, and the duration of PDR was significantly shortened in groups S1-S3 ( P<0.05). Compared to group S1, the disappearance rate of PDR was significantly increased, and the latency of PDR was prolonged in S2 and S3 groups ( P<0.05). Conclusions:The inhibitory effect of sufentanil on the PDR during induction of general anesthesia is dose-dependent.
