Effect of terlipressin combined with dopamine on intraoperative renal perfusion and early postoperative renal function in patients undergoing living-donor kidney transplantation
10.3760/cma.j.cn131073-20241011-00606
- VernacularTitle:特利加压素复合多巴胺对活体肾移植患者术中肾灌注及术后早期肾功能的影响
- Author:
Jinfu WU
1
;
Shaoxuan LIU
;
Hui DAI
;
Lijuan WANG
;
Lihua JIANG
;
Feng JIN
Author Information
1. 郑州大学第一附属医院麻醉与围术期及疼痛医学部，郑州 450052
- Publication Type:Journal Article
- Keywords:
Terlipressin;
Dopamine;
Kidney transplantation;
Renal perfusion;
Renal function
- From:
Chinese Journal of Anesthesiology
2025;45(6):698-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of terlipressin combined with dopamine on intraoperative renal perfusion and early postoperative renal function in patients undergoing living-donor kidney transplantation.Methods:In this prospective cohort study, 84 patients of either sex, aged 18-64 yr, with a body mass index of 18.5-28.0 kg/m 2, of American Society of Anesthesiologists Physical Status classification Ⅲ or Ⅳ, undergoing living-donor kidney transplantation at the First Affiliated Hospital of Zhengzhou University from September 2022 to July 2024, in whom dopamine was continuously infused during operation to maintain fluctuation in the mean arterial pressure within 10% of the baseline value, were selected and divided into dopamine group (group D, n=42) and dopamine+ terlipressin group (group DT, n=42) based on whether terlipressin was used during operation. Terlipressin was continuously infused at a constant rate even before induction in group DT. The renal artery resistance index, intraoperative urine output, urine output within 24 h after surgery, concentration of creatinine within 7 days after surgery, glomerular filtration rate and delayed postoperative transplanted renal function were recorded. Results:Compared with group D, the intraoperative renal vascular resistance index was significantly reduced, the intraoperative urine output was increased ( P<0.01), and no statistical change was found in the urine output within 24 h after surgery, concentration of creatinine within 7 days after surgery, glomerular filtration rate and incidence of delayed postoperative transplanted renal function in group DT ( P>0.05). Conclusions:Terlipressin combined with dopamine provides better efficacy than dopamine alone in improving intraoperative renal perfusion and exerts no effect on early postoperative renal function in patients undergoing living-donor kidney transplantation.
