Comparison of anesthetic potency of ciprofol combined with alfentanil in patients with different BMIs during gastroscopy
10.3760/cma.j.cn131073.20240403.01215
- VernacularTitle:复合阿芬太尼时环泊酚用于不同BMI患者胃镜检查术麻醉效力的比较
- Author:
Jin HUANG
1
;
Jiashuo ZHANG
1
;
Shengyu WANG
1
;
Yanan HAN
1
;
Bowei JIANG
1
;
Fengdan MA
1
;
Chunguang WANG
1
Author Information
1. 保定市第一中心医院麻醉科，保定 071000
- Publication Type:Journal Article
- Keywords:
Body weight changes;
Ciprofol;
Alfentanyl;
Gastroscopy;
Dose-effect relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(12):1476-1479
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the anesthetic potency of ciprofol combined with alfentanil in patients with different body mass indexes (BMIs) during gastroscopy.Methods:American Society of Anesthesiologists Physical Status classification I or Ⅱ patients, aged 18-64 yr, with a BMI of 18-36 kg/m 2, undergoing elective painless gastroscopy at Baoding First Central Hospital from October to December 2023, were divided into 3 groups: normal group (18 kg/m 2≤BMI<24 kg/m 2), overweight group (24 kg/m 2≤BMI<28 kg/m 2) and obesity group (BMI≥28 kg/m 2). The 95% effective dose (ED 95) of ciprofol during painless gastroscopy was determined by the biased coin design. Alfentanyl 5 μg/kg and ciprofol were intravenously injected for anesthesia induction. Gastroscopy was performed after the patient′s eyelash reflex disappeared, the jaw muscle was relaxed and the Modified Observer′s Assessment of Alertness/Sedation Scale score ≤ 1. The initial dose of ciprofol was 0.2 mg/kg with a dose gradient of 0.04 mg/kg. The positive response were defined as the Modified Observer′s Assessment of Alertness/Sedation Scale score still> 1 after 3 min of ciprofol injection or any other responses affecting the procedure, such as body movement, bucking, or swallowing during insertion of the endoscope. If the response was positive, the next patient received a higher dose of ciprofol, or conversely if negative, the next patient received the same dose (95% probability) or a lower dose (5% probability). Each group was completed with 40 cases. Results:The ED 95 and 95% confidence intervals of ciprofol in normal, overweight and obese groups were 0.266 (0.246, 0.285) mg/kg, 0.218 (0.189, 0.244) mg/kg, 0.191 (0.156, 0.220) mg/kg, respectively. The ED 95 of ciprofol was significantly lower in overweight and obese groups than in normal group ( P<0.05). Conclusions:Overweight and obesity can increase the anesthetic potency of ciprofol in patients undergoing gastroscopy.
