Pro-tumorigenic mechanisms of tumor-associated macrophages in oral cancer
10.12354/j.issn.1000-8179.2025.20250361
- VernacularTitle:肿瘤相关的巨噬细胞在口腔癌中的促癌机制
- Author:
Xu XIAOYI
1
;
Wang BIN
;
Yang MENGMENG
;
Shen JUN
Author Information
1. 天津市人民医院,南开大学第一附属医院口腔科(天津市 300121)
- Publication Type:Journal Article
- Keywords:
oral cancer;
tumor-associated macrophages(TAMs);
clinical significance
- From:
Chinese Journal of Clinical Oncology
2025;52(15):783-790
- CountryChina
- Language:Chinese
-
Abstract:
Oral cancer is a common inflammation-associated malignant tumor of the head and neck.In recent years,the role of the tumor microenvironment in the progression of oral cancer has received increasing attention.In the microenvironment of solid tumors,including or-al cancer,tumor-associated macrophages(TAMs)are among the most common type of immune cell and are closely associated with the poor prognosis of more than 80%of human malignant tumors.An increasing body of evidence indicates that TAMs play important roles in the oc-currence and progression of oral cancer.On the basis of the most recent research progress,both domestic and international,we systematic-ally reviewed the phenotypic characteristics,clinicopathological correlations,and molecular regulatory mechanisms of TAMs in the microen-vironment of oral squamous cell carcinoma(OSCC).In particular,we focus on the key signaling pathways promoting tumorigenesis and de-velopment and immune escape mechanisms,with the aim of constructing a systematic theoretical framework for developing therapeutic strategies targeting TAMs and providing a scientific basis for clinical translational research.
