Relationship between neutrophil-to-lymphocyte ratio during perioperative period and early postoperative recurrence in patients with advanced gastric cancer
10.3760/cma.j.cn131073-20241209-00605
- VernacularTitle:围术期中性粒细胞/淋巴细胞比值与进展期胃癌患者术后早期复发的关系
- Author:
Fangfang YONG
1
;
Wei LIU
1
;
Weiai JIA
1
;
Hemei WANG
1
;
Zhijiao WANG
1
;
Huiqun JIA
1
Author Information
1. 河北医科大学第四医院麻醉科，石家庄 050011
- Publication Type:Journal Article
- Keywords:
Neutrophils;
Lymphocytes;
Stomach neoplasms;
Recurrence
- From:
Chinese Journal of Anesthesiology
2025;45(6):694-697
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the relationship between the neutrophil-to-lymphocyte ratio (NLR) during the perioperative period and early postoperative recurrence in patients with advanced gastric cancer.Methods:In this prospective study, 188 American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients, aged 18-75 yr, with a body mass index of 20-30 kg/m 2, with radiological staging of T 2-4N xM 0, underwent elective gastric cancer radical surgery under general anesthesia at the Fourth Hospital of Hebei Medical University from January 2018 to April 2022, were selected. The NLR was measured at 1 day before operation and postoperative days 1, 3 and 5. The difference between postoperative and preoperative NLR (ΔNLR) was calculated. Based on the presence or absence of tumor recurrence and/or metastasis within 2 yr after surgery, the patients were divided into recurrence group and non-recurrence group. The Cox proportional hazards regression model was employed to evaluate the early postoperative recurrence and perioperative NLR in patients with advanced gastric cancer. Results:A total of 171 patients ultimately completed the follow-up. There were 77 cases in recurrence group and 94 in non-recurrence group. Compared to non-recurrence group, NLR and ΔNLR were significantly increased on the 5th day after operation in recurrence group ( P<0.05). The elevated NLR and ΔNLR at postoperative day 5 were independent risk factors for recurrence within 2 yr in patients with advanced gastric cancer ( HR=1.026, P<0.05). Conclusions:NLR may not be associated with the risk of early postoperative recurrence in the patients with advanced gastric cancer, and further evaluation with large-scale studies is needed.
