Effect of age factor on potency of oliceridine in inhibiting responses to gastroscopic implantation when combined with propofol
10.3760/cma.j.cn131073.20240715.01211
- VernacularTitle:年龄因素对复合丙泊酚时奥赛利定抑制胃镜置入反应效力的影响
- Author:
Jia JIA
1
;
Guoshuang LI
;
Beibei ZHANG
;
Jiaqiang ZHANG
;
Wei ZHANG
Author Information
1. 河南省人民医院（郑州大学人民医院）麻醉与围术期医学科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Age factors;
Analgesics, opioid;
Propofol;
Gastroscopy;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(12):1456-1459
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of age factor on the potency of oliceridine in inhibiting responses to the gastroscopic implantation when combined with propofol.Methods:This was a prospective study. American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients of either sex, with a body mass index of 18-27 kg/m 2, undergoing elective painless gastroscopy, were divided into 2 groups based on age: adult group (group A: age 18-65 yr) and elderly group (group E: age>65 yr). Propofol 1.5 mg/kg was slowly injected intravenously 2 min after intravenous injection of oliceridine. Gastroscopy was performed after the patient′s eyelash reflex disappeared and the jaw was relaxed. The optimal dose was determined by modified Dixon′s up and down method. The initial dose of oliceridine was 0.015 mg/kg, and the ratio between the two successive concentrations was 1.0 ∶1.2. If the patient had a positive response that affected the examination operation such as swallowing, bucking and body movement during insertion of the gastroscope, the next patient received a higher dose, or conversely if negative, and a lower dose was given in the next patient. This process was repeated until the 7th turning point occurred. The median effective dose (ED 50) and 95% confidence interval of oliceridine in inhibiting responses to gastroscopic implantation were calculated by probit method. Results:The ED 50 (95% confidence interval) of oliceridine in inhibiting responses to gastroscopic implantation was 0.015 (0.007-0.023) mg/kg and 0.012 (0.007-0.017) mg/kg in group A and group E, respectively. There was no significant difference in ED 50 between the two groups ( P>0.05). Conclusions:Age factor has no significant effect on the potency of oliceridine in inhibiting responses to gastroscopic implantation when combined with propofol.
