Median effective dose of oliceridine combined with propofol for analgesia during induced abortion in patients with different labor histories
10.3760/cma.j.cn131073.20240919.01207
- VernacularTitle:复合丙泊酚时奥赛利定用于不同分娩史患者人工流产术镇痛的半数有效剂量
- Author:
Beibei ZHANG
1
;
Wei ZHANG
1
;
Jia JIA
1
;
Zhenli WANG
1
;
Guoshuang LI
1
;
Jiaqiang ZHANG
1
Author Information
1. 河南省人民医院（郑州大学人民医院）麻醉与围术期医学科，郑州 450003
- Publication Type:Journal Article
- Keywords:
Analgesics, opioid;
Propofol;
Abortion, induced;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(12):1437-1440
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the median effective dose (ED 50) of oliceridine combined with propofol for analgesia during induced abortion in patients with different labor histories. Methods:This was a prospective study. American Society of Anesthesiologists Physical Status classification I or Ⅱ patients, aged 18-45 yr, with a body mass index of 20-28 kg/m 2, scheduled for elective induced abortion at Henan Provincial People′s Hospital (Zhengzhou University People′s Hospital) from July 1, 2024 to August 20, 2024, were selected. Patients were divided into a delivery group (group D) and a non-delivery group (group N) based on their histories of vaginal delivery. The modified Dixon′s up and down method was used to conduct the trial. Oliceridine was intravenously injected at a dose of 0.015 mg/kg in the first patient in each group, and the dose was determined based on the intraoperative body movement. The positive response was defined as the body movement of grade 2 or higher during induced abortion. If the response was positive, the next patient received a higher dose of oliceridine, or conversely, a lower dose was given. The ratio between the two successive concentrations was 1.2, and the trial was terminated until 7 turning points were achieved. The ED 50 and 95% confidence interval were calculated using the Dixon sequential method formula. The occurrence of adverse reactions was recorded. Results:A total of 54 patients were included in this study, with 25 in group D and 29 in group N. The ED 50 and 95% confidence interval of oliceridine for painless abortion were 0.019 (0.014-0.031) mg/kg and 0.026 (0.020-0.044) mg/kg in group D and group N, respectively. Compared with group D, the ED 50 of oliceridine for analgesia during induced abortion was significantly increased when combined with propofol in group N ( P<0.05). Patients in both groups experienced dizziness after intravenous oliceridine injection, and no other adverse reactions such as injection pain were observed. Conclusions:When combined with propofol, the ED 50 of oliceridine for analgesia is 0.019 mg/kg and 0.026 mg/kg during induced abortion in patients with and without vaginal delivery history, respectively. The analgesic potency of oliceridine is decreased in patients without a history of vaginal delivery compared to patients with a history of vaginal delivery.
