Median effective dose of oliceridine combined with propofol for analgesia during induced abortion
10.3760/cma.j.cn131073.20241022.01209
- VernacularTitle:复合丙泊酚时奥赛利定用于人工流产术患者镇痛的半数有效剂量
- Author:
Yuhong LI
1
;
Fan MENG
1
;
Jia QIU
1
;
Ning YIN
1
Author Information
1. 南京医科大学附属逸夫医院麻醉科，南京 221000
- Publication Type:Journal Article
- Keywords:
Analgesics, opioid;
Propofol;
Abortion, induced;
Dose-response relationship, drug
- From:
Chinese Journal of Anesthesiology
2024;44(12):1446-1449
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the median effective dose (ED 50) of oliceridine for analgesia during induced abortion when combined with propofol. Methods:In this prospective study, 24 American Society of Anesthesiologists Physical Status classification Ⅰ or Ⅱ patients, aged 20-45 yr, with a body mass index of 18-26 kg/m 2, who underwent painless induced abortion surgery at Sir Run Run Hospital affiliated to Nanjing Medical University from September to October 2024, were selected. The modified Dixon sequential method was used for the study. The initial dose of oliceridine was 0.025 mg/kg, and 2 min later propofol 2 mg/kg was intravenously injected. The ratio between the two successive doses of oliceridine was 1.0∶1.1. If the patient experienced inadequate analgesia during cervical dilation (frowning, moaning, involuntary limb movements, increase in heart rate or mean arterial pressure greater than 20% of baseline), the next patient received a higher dose of oliceridine, or conversely, a lower dose was given. The study was terminated when 7 turning points from inadequate analgesia to adequate analgesia were achieved. Dixon sequential trial formula was used to calculate the ED 50 of oliceridine and the confidence interval. The occurrence of adverse reactions such as intraoperative hypoxemia, postoperative dizziness and nausea and vomiting was recorded. Results:Twenty-four patients were ultimately included in this study. When combined with propofol 2 mg/kg, the ED 50 of oliceridine for analgesia during painless induced abortion surgery was 0.019 mg/kg (95% confidence interval 0.018-0.021 mg/kg). One patient developed hypoxemia, and two patients experienced mild dizziness after surgery. All patients had no nausea or vomiting. Conclusions:When combined with 2 mg/kg of propofol, the ED 50 of oliceridine for analgesia during is 0.019 mg/kg induced abortion surgery.
