Association between white matter hyperintensities and impaired dopaminergic system function in patients with PD
10.3969/j.issn.1009-0126.2025.10.004
- VernacularTitle:帕金森病患者脑白质高信号和多巴胺能系统功能受损的关联
- Author:
Wanlin LI
1
;
Ai GUAN
1
;
Xinyi XIE
1
;
Yunlan DU
1
;
Ruolian DAI
1
;
Zhongjiao LU
1
;
Gang CHEN
1
;
Qing DONG
1
;
Hualong WANG
1
;
Gang WANG
1
Author Information
1. 200127 上海交通大学医学院附属仁济医院神经内科
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
leukoencephalopathies;
positron-emission tomography
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(10):1304-1308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze white matter hyperintensities(WMH)and 11C-CFT PET/CT characteristics in patients with PD,and explore their relationship.Methods A total of 84 PD pa-tients admitted to our department between March 2021 and March 2025 were retrospectively en-rolled,and they were divided into young group(33 cases)and elderly group(aged＞65 years,51 cases)and also into non-WMH group(22 cases)and WMH group(62 cases)based on the severity of WMH.The degree of white matter lesions was scored,including periventricular white matter hyperintense(PVH)score and deep white matter hyperintense(DWMH)score.All patients un-derwent head MRI and 11C-CFT-PET/CT scanning.The T/N value and asymmetry index were calculated.Results The elderly PD patients exhibited significantly advanced age and higher H-Y stages,but lower T/N values of affected side of caudate nucleus,contralateral caudate nucleus,affected side of anterior putamen,contralateral anterior putamen and contralateral posterior puta-men,and posterior putamen asymmetry index than the young patients(P＜0.05,P＜0.01).Simi-lar results were observed in the WMH group when compared with the non-WMH group(P＜0.05,P＜0.01).The PVH score was negatively correlated with the T/N values of affected side of caudate nucleus(r=-0.282,P=0.009),contralateral caudate nucleus(r=-0.215,P=0.049),affected side of anterior putamen(r=-0.249,P=0.022),contralateral anterior putamen(r=-0.280,P=0.010)and contralateral posterior putamen(r=-0.285,P=0.009),and DWMH score was also negatively correlated with the T/N values in the affected side of caudate nucleus and affected side of anterior putamen(P＜0.05).Conclusion Both age and disease severity impact WMH and dopaminergic system in PD patients.A higher WMH load is associated with dopamin-ergic neuronal damage.
