Efficacy of nimodipine combined with donepezil on cerebral small vessel disease patients with mild cognitive impairment
10.3969/j.issn.1009-0126.2025.10.006
- VernacularTitle:尼莫地平联合多奈哌齐治疗脑小血管病轻度认知功能障碍的疗效分析
- Author:
Yun NI
1
;
Zhihua LUO
1
;
Yuan WANG
1
;
Xueqin ZHOU
1
;
Zhuqiang HE
1
Author Information
1. 430022 武汉市第一医院神经外科
- Publication Type:Journal Article
- Keywords:
cerebral small vessel diseases;
cognitive dysfunction;
donepezil;
Nimodipine
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(10):1313-1316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of nimodipine combined with donepezil in the treatment of CSVD patients with mild cognitive impairment.Methods A total of 130 CSVD pa-tients admitted to our department from October 2020 to October 2023 were recruited and ran-domly divided into monotherapy group(nimodipine,65 cases)and combined group(nimodipine plus donepezil,65 cases).The clinical efficacy after 3 months of treatment was recorded.The blood-brain barrier function and brain function indicators[serum neuron-specific enolase(NSE),vascular endothelial growth factor(VEGF),central nervous system specific protein(S100β)]were compared between the two groups.Results The clinical efficacy was significantly higher in the combined group than the monotherapy group(92.3％vs 78.5％,P＜0.05).The cerebrospinal fluid albumin and blood-brain barrier index were obviously increased in the two groups after treatment(P＜0.05),and the two indicators were notably lower in the combined group than the monothera-py group(P＜0.01).After treatment,the level of VEGF was remarkably elevated while those of NSE and S100β were marvelously reduced in the two groups when compared with the levels be-fore treatment(P＜0.05).The combined group obtained significantly higher VEGF level but low-er NSE and S100β levels than the monotherapy group after treatment(P＜0.01).Conclusion For CSVD patients with mild cognitive impairment,the combination of nimodipine and donepezil can effectively improve the cognitive impairment,and promote the brain function recovery.
